Chapter 20: Carboxylic Acid Derivatives. Nucleophilic Acyl Substitution

Interconversion Reactions of Amides

Summary

• Amides are the least reactive of the neutral carboxylic acid derivatives.
• The only interconversion reaction that amides undergo is hydrolysis back to the parent carboxylic acid and the amine.
• Reagents : Strong acid (e.g. H₂SO₄) or strong base (e.g. NaOH) / heat.
• More details on the following page.

© Dr. Ian Hunt, Department of Chemistry