Part 9: SYNTHESIS

The schemes below give possible syntheses of the targets. There are of course other variations. The first part for each compound gives a "retro-synthesis", the "plan" and then the required forward synthesis with reagents is given. Red arrows try to show carbon-carbon bond forming reactions, blue arrows are functional group manipulations. The blue text rationalise the retrosynthetic analysis and information about important reactions are given in green.


alkene synthesis


ketal synthesis

Note.... stereochemistry of the diol is important here.... this means the right alkene stereochemistry with the right addition stereochemistry to give the required diol. Here we have shown simple alcohol dehydration which favours the trans-alkene and follow that with the syn addition to get the diol.


alcohol synthesis


amide synthesis


bromide synthesis


ester synthesis


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