Chapter 27: Amino Acids, Peptides and Proteins
Preparation of Amides
(review of Chapter 20)
Reaction type: Nucleophilic Acyl Substitution
Summary
Primary amines,
R-NH
2
and secondary amines,
R
2
-NH
undergo
nucleophilic acyl substitution
with carboxylic acid derivatives to give
amides
.
The most common examples are the reactions of
acid chlorides
and
anhydrides
, though esters do react with amines.
©
Dr. Ian Hunt
, Department of Chemistry, University of Calgary
