Chapter 6: Acidity and Basicity

Structural Factors affecting Acidity : Resonance

Impact : large.... ΔpKa approx. 10 units / effect e.g. consider CH3OH (pKa = 15) vs CH3CO2H (pKa = 5)

ACIDITY : Look for factors that stabilise the conjugate base...we do this by simply removing the H+:

© Dr. Ian Hunt, Department of Chemistry