Chapter 21: Ester Enolates
In some molecules there are
atoms that are adjacent to
carbonyl groups (which are
Extra resonance stabilisation of the enolate anion makes these
more acidic (
pKa) than hydrogens adjacent to a single carbonyl group.
These type of compounds are sometimes called "
" (recall a methylene group is a CH
Some common active methylene compounds are shown below as JMOL images.... make sure you can see the acidic active methylene hydrogen atoms.....
As we will see
later is this Chapter
, these compounds are useful synthetic intermediates.
Their enolates can be formed readily and can be alkylated, then further manipulated.
Dr. Ian Hunt
, Department of Chemistry, University of Calgary