|Chapter 20: Carboxylic Acid Derivatives. Nucleophilic Acyl Substitution|
Nucleophilic Acyl Substitution : Reactive Systems
The nucleophile adds to the electrophilic C in the polar carbonyl group, electrons from the C=O move to the electronegative O creating the tetrahedral intermediate.
The intermediate collapses, reforming the strong C=O bond results in the loss of the leaving group, leading to the new carbonyl containing system.
© Dr. Ian Hunt, Department of Chemistry, University of Calgary